Clinicians Sunshine Vitamin D

• Supports immunity by enhancing the ability of white blood cells to identify and attack pathogenic substances in the body.
• Plays a preventative role in inflammation through down regulation of pro-inflammatory cytokines (chemical mediators that enhance the immune response) and biomarkers. This is particularly important in cardiovascular disease and osteoporosis.
• Promotes calcium homeostasis by ensuring that vitamin D3 is available to facilitate intestinal absorption of calcium. Ensures vitamin K is available for vitamin K-dependant proteins (such as osteocalcin and matrix GLA) which are involved in mineralisation of bones and teeth.
• Promotes healthy muscle cell metabolism through enhancing vitamin D3 receptors found in skeletal muscles ensuring the uptake calcium.
• Supports the maintenance and restoration of insulin release through D3 receptors found in the pancreas (as yet the mechanism of how this works is not fully understood).
• Aids in the prevention or coronary heart disease and promotes heart health. Vitamin D3 has a role in the suppression of cardiac hypertrophy (similarly the mechanism of how this process is facilitated is not yet known).

Ingredients

Active Ingredients per gelatin capsule:

Vitamin D3 (cholecalciferol 1000IU) 25mcg

Vitamin K2 (menaquinone MK7) 90mcg

No added: Gluten, dairy, yeast, sugar, artificial colours, sweeteners, flavours or preservatives.

Also Contains: Xylitol, sorbitol, vegetable stearate, silica, cellulose and natural flavour. Contains Soy.

Directions

Adults and children over 3 years of age take 1 tablet daily dissolved under the tongue or as professionally advised.

Cautions

Exercise caution in patients with hypercalcaemia and/or primary hyperparathyroidism as vitamin D supplementation may increase urinary calcium excretion. Regular monitoring of serum and urinary calcium is advised if taking supplemental vitamin D.

Exercise caution in patients with other disorders of calcium metabolism such as sarcoidosis, hypercalciuria, tuberculosis, fungal granulomas, berylliosis and lymphomas. These disorders are associated with a dysregulation in vitamin D production and additional vitamin D can raise calcium levels and increase the risk of renal stones and renal failure. Regular monitoring of serum calcium is advised if taking supplemental vitamin D.

Exercise caution in patients taking anticoagulant medication such as warfarin as vitamin K2 may reduce the anticoagulant effect of such medication. Of note, doses of up to 100mcg/day of vitamin K do not appear to interfere with warfarin and may actually reduce international normalised ratio (INR) fluctuations. In addition Coenzyme Q-10 (CoQ10) is chemically similar to vitamin K2 and therefore has the ability to promote coagulation like vitamin K2.45 Taking both vitamin K2 (as found in Clinicians Sunshine Vitamin D3) and CoQ10 together may cause an additive effect thereby increasing the risk of clotting in people taking anticoagulants.

Side effects: Vitamin D is considered safe and well tolerated when the daily intake does not exceed the tolerable upper intake of 50mcg (2000IU) per day. No adverse effects have been documented at doses 5-fold above the tolerable upper intake. Similarly vitamin K is considered safe and well tolerated when used orally and appropriately. Pregnancy and Breastfeeding: Supplemental vitamin D during pregnancy and breast feeding is considered safe when doses do not exceed the tolerable upper intake level (50mcg or 2000IU per day). Supplemental vitamin K is considered safe during pregnancy when used in amounts that do not exceed the recommended dietary allowance (90mcg/day for women aged 19-50 years).